Pandemic Legacy Season 1, Red Box
Pandemic Legacy Season 1 plays very much like vanilla Pandemic but with a twist. Every couple of games you get to open doors or little boxes that add little mini expansions to the game with new characters to play as well as other things best experienced yourself.
Be warned that you're expected to put stickers on your game board and cards so you can only play threw the campaign once. It'll take 12 to 24 games to complete the campaign, to be fair most people don't play the same board game that often ever anyways.
There is no difference in game play between the red or blue box.